Spravato® (Esketamine) Nasal Spray Treatment

A Breakthrough Option for Treatment-Resistant Depression

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A New Option When Traditional Treatments Haven’t Worked

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For individuals living with treatment-resistant depression (TRD) or major depressive disorder (MDD) with suicidal thoughts, Spravato® (esketamine) offers a new approach to symptom relief—especially when standard antidepressants haven't been effective.

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Spravato is a fast-acting nasal spray medication that works differently than most oral antidepressants. It targets the NMDA receptor in the brain and helps restore healthy neural connections, which can lead to rapid improvements in mood, energy, and overall functioning. Many patients begin to notice changes within hours or days—not weeks.

 

How Spravato Treatment Works

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Spravato is administered in-office under the supervision of a licensed medical professional. Treatment sessions typically involve resting in a safe, quiet environment for about two hours after the spray is given, allowing our staff to monitor your response and ensure your comfort and safety.

 

Treatment begins with two sessions per week for the first four weeks, then gradually tapers based on your individual progress and treatment plan.

 

Supportive Care for Your Mental Health Journey

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At Brio Neurobehavioral Consultants, we understand the complexity of mental health conditions. Our experienced psychiatric team works closely with each patient to develop a personalized plan that may include Spravato alongside ongoing therapy, medication management, and other supportive services.

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If you’ve tried multiple antidepressants with little or no improvement, Spravato may be a helpful next step in your recovery. ​ Contact us to learn more or to schedule an evaluation with our care team.